Lexical Crosslinguistic Influence and Study Abroad: Do Learners Use L1-Based Resources Less?

Research in Crosslinguistic Influence (CLI) has traditionally addressed two broad types of lexical CLI transfer of form and transfer of meaning (Ringbom 1987) which were reconceptualized by Jarvis (2009) as lexemic and lemmatic transfer, respectively. Whereas the former considers the phonological and graphemic structure of words, the latter is related to semantic and syntactic properties. These types of lexical CLI have been analysed in relation to L2 proficiency, but not in relation to factors such as Study Abroad (SA), which the present study aims to investigate. The oral production by 107 Catalan/Spanish learners of English as a Foreign Language (EFL) was analysed in terms of lexical CLI and the amount of input received during their SA. Results show an inverse relationship between the amount of input in SA and lexical CLI; that is, the higher the number of hours abroad, the fewer cases of lexical CLI. Statistical differences were found for lemmatic CLI and for one type of lexemic CLI. In light of these findings, it is suggested that learners that take part in SA programmes do not rely on L1-based resources when gaps in their knowledge arise

(Re)pensando la rehabilitación en salud mental en el contexto de pandemia por COVID-19. Experiencia práctica de la re adecuación y la accesibilidad a Hospital de Día

El presente trabajo se enmarca dentro de la residencia de Trabajo Social en el Hospital de Emergencias Psiquiátricas “Torcuato de Alvear” del Gobierno de la Ciudad Autónoma de Buenos Aires. Este surge a partir de la inserción y rotación en el Servicio de Hospital de Día y del trabajo en equipos interdisciplinarios compuestos por medicxs psiquiatras, licenciadxs en psicología, licenciadxs en trabajo social, terapistas ocupacionales y enfermerxs. Dentro del mismo se intenta dar cuenta de cómo la emergencia epidemiológica de pandemia por COVID-19 y los procesos de Aislamiento Social Preventivo Obligatorio y de Distanciamiento Social Preventivo Obligatorio para evitar la propagación del virus, implicaron una redefinición y la readecuación de las estrategias de intervención en rehabilitación por salud mental. El nuevo contexto convocó a lxs profesionales a poner en juego su capacidad creativa para aggiornar las estrategias de intervención, la modalidad de atención y del acompañamiento de la grupalidad generando nuevos canales de accesibilidad a la salud. El objeto del trabajo es el de reflexionar sobre las estrategias de intervención desarrolladas para acompañar los procesos de rehabilitación en salud mental de lxs usuarixs en el contexto de pandemia por COVID-19. El proceso de readecuación y redefinición de las intervenciones permitió pensar la rehabilitación de salud mental como una nueva forma de re-habitar la institución y re-pensar diferentes estrategias de trabajo sobre el lazo social. Para dar cuenta de estos procesos que orientaron y redefinieron las prácticas, en un primer momento, se realizará una breve descripción del Servicio de Hospital de Día. --Fil: Di Mare Duran, Ma. Luciana. Universidad Nacional Villa María; Argentina.

Miedo ante la muerte y calidad de vida en adultos mayores

Objective: Know the relationship between the fear of death and the quality of life ofolder adults.Materials and Method: Correlational study in older adults. The sample was 99 older adults. The original Collet-Lester Scale of Death Fear and the Dying Process and the WHOQOL-BREF Questionnaire were used.Results: No relationship found on the global scale of Death Fear and the Dying Process with the quality of life. A negative relationship was observed between the fear of own death and the physical dimension of the quality of life (p<.05), and the fear of the process of dying with the environmental dimension of quality of life (p<.05). Positive relationship was found between the fear of the death of others and the social dimension of quality of life (p <.05).Conclusions: A lesser fear of one's own death higher quality of life in the physical dimension, a lesser fear of the process of dying, greater quality of life in the environmental dimension and the greater the fear of the death of other people, the greater the quality of life in the social dimension.Objetivo: Conocer la relación entre el miedo a la muerte y calidad de vida de los adultos mayores. Material y Método: Estudio correlacional en adultos mayores. La muestra fue de 99 adultos mayores, se utilizó la Escala original de Collet-Lester de Miedo a la Muerte y al Proceso de Morir y el Cuestionario WHOQOL-BREF. Resultados: No se encontró relación en la escala global del miedo ante la muerte y el proceso de morir con la calidad de vida. Se observó relación negativa entre el miedo a la propia muerte y la dimensión física de la calidad de vida (p<.05) y en el miedo al propio proceso de morir con la dimensión ambiental de la calidad de vida (p<.05). Se encontró relación positiva entre el miedo a la muerte de los otros y la dimensión social de la calidad de vida (p<.05). Conclusiones: A menor miedo a la propia muerte mayor calidad de vida en la dimensión física, a menor miedo al propio proceso de morir mayor calidad de vida en la dimensión ambiental y a mayor miedo a la muerte de otras personas mayor calidad de vida en la dimensión social

Analysis of embodied energy and product lifespan: the potential embodied power sustainability indicator

In the context of life cycle assessment sustainability indicators, this article proposes a new indicator that is related to the embodied energy, in order to assess the lifespan of products based on their components. The indicator, called 'potential embodied power' (PEP), considers that a non-replaceable component with a shorter lifespan will determine the lifetime of the product. The PEP indicator can be considered as an inherent property of the product, and it can be optimized by using a material selection method based on the concept of annualized embodied energy. This indicator can be used for product design decision making, since it determines the impact of product disposal in relation to the lifespan for which the product was designed. Also, a methodology is proposed to contribute to evaluating the environmental impact caused by the energy discarded resulting from the design decisions. A case study was performed on smartphones, and the results show that the variation of factors such as module lifespan or embodied energy allows achieving a lower value of the embodied power

Historias vividas del profesorado en el mundo digital

Este artículo tiene como finalidad aportar evidencias sobre la complejidad a la que se afrontan las escuelas y el profesorado a la hora de relacionarse con los cambios propiciados por las Tecnologías de la Información y la Comunicación (TIC) y con el uso educativo de las mismas. Comenzamos este artículo presentando la investigación de la que se deriva este texto y argumentando que las historias profesionales de vida constituyen evidencias valiosas para entender lo que sucede en las escuelas. A continuación nos centramos en la situación de las TIC en la educación. Todos los docentes que participaron en la investigación, menos uno, señalaron a las TIC como fuente de transformaciones y problemáticas importantes para la educación, y como objeto de cuestionamiento y reflexión personal y profesional, sean o no utilizadas en las aulas. Por ello abordamos esta temática desde tres ángulos. En primer lugar nos referimos brevemente a cómo las TIC están transformando la manera en la que los individuos se relacionan con la información y se sitúan frente al aprendizaje; para abordar la dificultad de los sistemas educativos para impulsar un uso de las TIC orientado a la mejora de la escuela y del aprendizaje de alumnos y profesores. Finalmente, y antes de pasar a las conclusiones, recogemos extractos de las vidas profesionales de once docentes que nos ofrecen su experiencia corporeizada en relación a las TIC

Alpha-particle-induced complex chromosome exchanges transmitted through extra-thymic lymphopoiesis in vitro show evidence of emerging genomic instability

Human exposure to high-linear energy transfer α-particles includes environmental (e.g. radon gas and its decay progeny), medical (e.g. radiopharmaceuticals) and occupational (nuclear industry) sources. The associated health risks of α-particle exposure for lung cancer are well documented however the risk estimates for leukaemia remain uncertain. To further our understanding of α-particle effects in target cells for leukaemogenesis and also to seek general markers of individual exposure to α-particles, this study assessed the transmission of chromosomal damage initially-induced in human haemopoietic stem and progenitor cells after exposure to high-LET α-particles. Cells surviving exposure were differentiated into mature T-cells by extra-thymic T-cell differentiation in vitro. Multiplex fluorescence in situ hybridisation (M-FISH) analysis of naïve T-cell populations showed the occurrence of stable (clonal) complex chromosome aberrations consistent with those that are characteristically induced in spherical cells by the traversal of a single α-particle track. Additionally, complex chromosome exchanges were observed in the progeny of irradiated mature T-cell populations. In addition to this, newly arising de novo chromosome aberrations were detected in cells which possessed clonal markers of α-particle exposure and also in cells which did not show any evidence of previous exposure, suggesting ongoing genomic instability in these populations. Our findings support the usefulness and reliability of employing complex chromosome exchanges as indicators of past or ongoing exposure to high-LET radiation and demonstrate the potential applicability to evaluate health risks associated with α-particle exposure.This work was supported by the Department of Health, UK. Contract RRX95 (RMA NSDTG)

Depresión, ansiedad, función cognitiva y dependencia funcional en adultos mayores hospitalizados

Objective: Determine the relationship between depression, anxiety, and cognitive function with dependency in older adults.Materials and Method: Descriptive and correlational cross-sectional study conducted on 98 hospitalized older adults. The Hospital Anxiety and Depression Scale, the Montreal Cognitive Evaluation Test, and the Barthel Index were applied. Results: Age, gender, depression, anxiety, and cognitive function explain 33% of functional dependency. The variables that influence dependence to carry out basic activities in daily life were gender (p = .000), depression (p = .002), and cognitive function (p =.002).Conclusions: In assessing the functionality of hospitalized older adults, gender, depression, and cognitive function are important to consider.Objetivo: Determinar la relación entre la depresión, ansiedad y función cognitiva con la dependencia en adultos mayores.Material y Método: Estudio descriptivo y correlacional de corte transversal en 98 adultos mayores hospitalizados. Se aplicó la Escala Hospitalaria de Ansiedad y Depresión, el test de evaluación cognitiva de Montreal e Índice de Barthel.Resultados: La edad, el género, la depresión, la ansiedad y la función cognitiva explican el 33% de la dependencia funcional. Las variables que influyen sobre la dependencia en las actividades básicas de la vida diaria fueron el género (p=.000), la depresión (p=.002) y la función cognitiva (p=.002).Conclusiones: En la valoración de la funcionalidad del adulto mayor hospitalizado es importante considerar el género, la depresión y la función cognitiva.Resumo:Objetivo: determinar a relação entre depressão, ansiedade e função cognitiva com dependência em idosos.Material e Método: Estudo transversal descritivo e correlato em 98 idosos hospitalizados. Foi aplicada a Escala de Ansiedade e Depressão Hospitalar, o Teste de Avaliação Cognitiva de Montreal e o Índice de Barthel.Resultados: Idade, sexo, depressão, ansiedade e função cognitiva explicam 33% da dependência funcional. As variáveis que influenciam a dependência das atividades básicas da vida cotidiana foram sexo (p.000), depressão (p.002) e função cognitiva (p.002).Conclusões: Ao avaliar a funcionalidade do idoso hospitalizado é importante considerar gênero, depressão e função cognitiva

Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies

The incidence of obesity and its related disorders has increased dramatically in recent years and has become a pandemic. Adipose tissue is a crucial regulator of these diseases due to its endocrine capacity. Thus, understanding adipose tissue metabolism is essential to finding new effective therapeutic approaches. The 'omic' revolution has identified new concepts about the complexity of the signaling pathways involved in the pathophysiology of adipose tissue-associated disorders. Specifically, advances in transcriptomics have allowed its application in clinical practice and primary or secondary prevention. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of adipose tissue since they can modulate gene expression at the epigenetic, transcriptional, and post-transcriptional levels. They interact with DNA, RNA, protein complexes, other non-coding RNAs, and microRNAs to regulate a wide range of physiological and pathological processes. Here, we review the emerging field of lncRNAs, including how they regulate adipose tissue biology, and discuss circulating lncRNAs, which may represent a turning point in the diagnosis and treatment of adipose tissue-associated disorders. We also highlight potential biomarkers of obesity and diabetes that could be considered as therapeutic targets. Keywords: Adipose tissue; Biomarkers; Diabetes; Obesity; Therapeutics; lncRNA

REGULATION OF BETA-ADRENOCEPTORS ACTIVITYUSING SYNTHETIC LIGHT-REGULATED MOLECULES

Beta-adrenoceptors (ß-AR) are prototypical G proteincoupled receptors and important pharmacological targets for many diseases. Indeed, a number of approved drugs target these receptors due to their key role on many physiological functions. Among other examples, we encounter ß1-AR antagonists (ß- Blockers), which constitute the first-line therapy for the treatment of heart diseases, and ß2-AR agonists, which act as bronchodilators for the treatment of breathing pathologies. Considering the relevance of these receptors, achieving a reversible and localised control of their activity would provide a powerful tool, both for its research applications and its clinical potential. In this context, photopharmacology arises as a potent approach. Photopharmacology is an emerging field based on the use of synthetic light-regulated molecules to allow reversible spatiotemporal control of target receptors in native tissues. These ligands have the potential to provide a precise and controllable therapeutic action with increased efficacy and reduced side effects. Moreover, the fine regulation on demand of the receptor activation state is of great interest for their study in non-modified cells, tissues and organisms. The present project provides the first proof of concept for beta-adrenoceptor photopharmacology. We first designed and synthesised libraries of lightregulated compounds in order to regulate ß-AR activity with spatiotemporal precision. Subsequent testing highlighted the successful development of compounds with promising pharmacological properties which can be reversibly and irreversibly controlled by light. The discovered molecules enable a fine control of ß-AR in their native environment that will certainly open the door to innovative research procedures and may inspire future personalized therapies targeting these receptors

In vitro and in vivo regulation of ß-Adrenoceptors signaling using synthetic light-regulated molecules

Beta-adrenoceptors (ß-AR) are prototypical G protein-coupled receptors (GPCR) and important pharmacological targets for numerous diseases. Indeed, a number of approved drugs target ß-AR, which are key regulators of many physiological functions. Among other examples, ß1-AR antagonists (known as ß-Blockers) are first-line therapies for the treatment of heart failure, and ß2-AR agonists, which act as bronchodilators, are widely used for the treatment of breathing pathologies. Considering the medical relevance of these receptors, achieving a reversible and localized control of their activity would provide a powerful research and clinical tool. GPCR signaling is currently recognized as a multidimensional process governed by molecular, spatial and temporal components. Uncovering the role of each of these dimensions is crucial to improve our knowledge on cell communication, to understand how different pathways give rise to cellular and physiological effects, and to know how can we interact with biological systems with precision using drugs. Photopharmacology is an emerging field in which light-sensitive molecules are used to control the function of a given target protein in native tissues. The modulation of the target activity is achieved by small, drug-like, photoregulated ligands. By the use of light, both spatial and temporal control of the compound activity can be achieved in unprecedented manners compared to conventional pharmacology. These ligands have the potential to provide highly precise and controllable therapeutic actions that may result in increased efficacies and reduced side effects. Importantly, photopharmacology may allow to gain mechanistic insight on the interplay between the activation time and the receptor location during signaling processes in non-modified cells, tissues and whole organisms. Our research focused on the generation of new molecular tools for beta-adrenoceptors photopharmacology will be presented in this communication. First, several libraries of light-sensitive compounds with the aim to regulate ß-AR activity with spatiotemporal precision were designed and synthesized. Subsequent testing in cell preparations demonstrated the successful development of compounds with promising pharmacological properties, which can be reversibly and irreversibly controlled by light. Among those, several hit compounds were identified as ligands for beta-1 and beta-2 adrenoceptors with low nanomolar activities. These libraries compounds were found to be active enough to become useful photopharmacological tools, so we also performed in vivo experiments to determine their research potential in physiological environments. Indeed, the discovered molecules enabled a fine control of ß-AR in their native environment. We believe that the results of these studies will certainly open the door to innovative research procedures and may inspire future therapies targeting ß-AR